A non-canonical EZH2/TRIM28 epigenetic axis drives heparan sulfate remodeling and melanoma metastasis
This study reveals that EZH2 drives melanoma metastasis through a non-canonical, methyltransferase-independent interaction with TRIM28 to upregulate the heparan sulfate-modifying enzyme SULF1, thereby remodeling the extracellular matrix to enhance cell migration and invasion.